Sodium Hydroxide → HCID 136005848, compound

HRID 915984Notes

Reaction equation

HRID 915984 reaction equation
[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:34]=[CH:33][C:20]([CH2:21][N:22]5[CH2:27][CH2:26][CH:25]([C:28]([O:30]CC)=[O:29])[CH2:24][CH2:23]5)=[CH:19][C:18]=4[O:35][CH3:36])=[N:11][C:10]=3[C:9]([CH3:37])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:34]=[CH:33][C:20]([CH2:21][N:22]5[CH2:27][CH2:26][CH:25]([C:28]([OH:30])=[O:29])[CH2:24][CH2:23]5)=[CH:19][C:18]=4[O:35][CH3:36])=[N:11][C:10]=3[C:9]([CH3:37])=[N:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136005846HCID 136005846, compound

Product 1

HCID 136005848HCID 136005848, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 1 ml ethanol solution of 43 mg (0.0848 mmol) of the compound obtained in Example 238, 1 ml of a 1M aqueous solution of sodium hydroxide was added, and the mixture was stirred at room temperature for 2 hours. Then, the reaction mixture was distilled under reduced pressure, and the residue was dissolved in water. Acetic acid was added, and precipitated solids were collected by filtration to obtain 21 mg (52%) of the captioned compound.

Workup

  1. distillationThen, the reaction mixture was distilled under reduced pressure
  2. dissolutionthe residue was dissolved in water
  3. additionAcetic acid was added
  4. customprecipitated solids
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f590362cd57f4ce6953c70ba21521672
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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