HCID 18677675, compound → HCID 136005899, compound

HRID 915985Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[N:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[N:15]=[C:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.Cl.[CH2:29]([N:31]([CH:42]1[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1)[C:32](=[O:41])[O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[CH3:30]>>[CH:17]1([N:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:45]5[CH2:44][CH2:43][CH:42]([N:31]([CH2:29][CH3:30])[C:32](=[O:41])[O:33][CH2:34][C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=6)[CH2:47][CH2:46]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[C:14]([CH3:23])=[N:15]2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

Reactant 2

HCID 18677675HCID 18677675, compound

HCID 136005880HCID 136005880, compound

Product 1

HCID 136005899HCID 136005899, compoundYield 47%

Procedure

The same reaction procedure as in Example 16 was performed, except that the compound obtained in Example 116 was used in place of the compound obtained in Example 15, and benzyl ethyl(4-piperidinyl)carbamate monohydrochloride was used in place of N-methylpiperazine. In this manner, 134 mg (47%) of the captioned compound was obtained.

Workup

customThe same reaction procedure as in Example 16

Sources & evidence

ORD record: ord-c36b643ab7ad488e8bed475e0a34c15c
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07268128B2

Reaction notes

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