1-Methylhomopiperazine → HCID 136005854, compound

HRID 915986Notes

Reaction equation

[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH2:28][CH3:29])=[N:11][C:10]=3[C:9]([CH3:30])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:31][N:32]1[CH2:38][CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23]([N:35]5[CH2:36][CH2:37][CH2:38][N:32]([CH3:31])[CH2:33][CH2:34]5)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH2:28][CH3:29])=[N:11][C:10]=3[C:9]([CH3:30])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 2283491-Methylhomopiperazine

HCID 136000721HCID 136000721, compound

Product 1

HCID 136005854HCID 136005854, compoundYield 83%

Procedure

The same reaction procedure as in Example 49 was performed, except that the compound obtained in Example 255 was used in place of the compound obtained in Example 48, and N-methyl-1,4-diazacycloheptane was used in place of N-methylpiperazine. In this manner, 145 mg (83%) of the captioned compound was obtained.

Workup

customThe same reaction procedure as in Example 49

Sources & evidence

ORD record: ord-ab3f4a769a3b4e6ea293a2be92415532
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07268128B2

Reaction notes

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