Hexahydro-1,4-diazepine → HCID 136005813, compound

HRID 915987Notes

Reaction equation

HRID 915987 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[N:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[N:15]=[C:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.[NH:28]1[CH2:34][CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH:17]1([N:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:28]5[CH2:34][CH2:33][CH2:32][NH:31][CH2:30][CH2:29]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[C:14]([CH3:23])=[N:15]2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 136005880HCID 136005880, compound

Product 1

HCID 136005813HCID 136005813, compoundYield 62%

Procedure

The same reaction procedure as in Example 16 was performed, except that the compound obtained in Example 116 was used in place of the compound obtained in Example 15, and homopiperazine was used in place of N-methylpiperazine. In this manner, 97 mg (62%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 16

Sources & evidence

ORD record
ord-09a047fa330f4181b58d17656be8a555
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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