Ethyl Acetate → HCID 178520335, compound

Participants

Reaction Conditions

Reaction Steps

1-{cis-4-[2-(2-Chloro-6-fluoro-phenyl)-acetylamino]-cyclohexyl}-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (400 mg) was dissolved in a mixture of THF (3.2 ml)/MeOH (3.2 ml)/H2O (1.6 ml) and LiOH.H2O (43 mg) was added. The reaction mixture was stirred 1 h at 60° C., then it was poured on a mixture of H2O (35 ml) and EtOAc (35 ml). The aqueous layer was collected, acidified with 1 M HCl to pH<4 and extracted with EtOAc (2×35 ml). After drying over Na2SO4 the solvent was evaporated to yield 341 mg (88%) of product. White powder. MS 379.1 (100, [M−H]−).

Provenance & Evidence