HCID 58959791, compound → HCID 9869063, compound

HRID 916057Notes

Reaction equation

HRID 916057 reaction equation
[Si]([O:8][C@H:9]([C:33]1[CH:38]=[CH:37][C:36]([OH:39])=[C:35]([CH2:40][OH:41])[CH:34]=1)[CH2:10][NH:11][C@H:12]([CH3:32])[CH2:13][C:14]1[CH:15]=[C:16]([CH2:20][C:21]([NH:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])=[O:22])[CH:17]=[CH:18][CH:19]=1)(C(C)(C)C)(C)C>O>[OH:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[CH2:24][NH:23][C:21](=[O:22])[CH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([CH2:13][C@H:12]([NH:11][CH2:10][C@H:9]([OH:8])[C:33]2[CH:38]=[CH:37][C:36]([OH:39])=[C:35]([CH2:40][OH:41])[CH:34]=2)[CH3:32])[CH:15]=1

Participants

3

Reactant 1

HCID 58959791HCID 58959791, compound

Product 1

HCID 9869063HCID 9869063, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 2-(3-{(2R)-2-[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-hydroxy3-hydroxymethyl-phenyl)-ethylamino]-propyl}-phenyl)-N-(2-hydroxy benzyl)-acetamide (Preparation 3) according to the method for example 1, using water instead of acetic acid as the co-solvent, to give the title compound as a white foam.

Sources & evidence

ORD record
ord-4141f44688a7415399c310b473f2b98d
Source dataset
uspto-grants-2007_09
Patent number
US07268147B2

Reaction notes

Loading…