HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 58959769 | HCID 58959769 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 58959760 | HCID 58959760 | — |
Reaction Steps
Prepared from 2-{3-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl]phenyl}-N-[(1R)-1 -phenylethyl]acetamide (Preparation 21) according to the method for example 3 using dichloromethane:methanol: 880 ammonia (90:10:1 by volume) as the column eluent to give the title compound as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268147B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-62ffc433d6fb4e7ca95fdf59a06b4f36 |
| Source note | uspto-grants-2007_09 |