HCID 68978329, compound → HCID 11466575, compound

HRID 916059Notes

Reaction equation

HRID 916059 reaction equation
[Si]([O:8][C@H:9]([C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[C:39]([CH2:44][OH:45])[CH:38]=1)[CH2:10][NH:11][C@H:12]([CH3:36])[CH2:13][C:14]1[CH:15]=[C:16]([CH2:20][C:21]([NH:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=2)=[O:22])[CH:17]=[CH:18][CH:19]=1)(C(C)(C)C)(C)C>CCOCC>[CH3:35][O:34][C:28]1[CH:27]=[C:26]([CH2:25][CH2:24][NH:23][C:21](=[O:22])[CH2:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([CH2:13][C@H:12]([NH:11][CH2:10][C@H:9]([OH:8])[C:37]3[CH:42]=[CH:41][C:40]([OH:43])=[C:39]([CH2:44][OH:45])[CH:38]=3)[CH3:36])[CH:15]=2)[CH:31]=[CH:30][C:29]=1[O:32][CH3:33]

Participants

3

Reactant 1

HCID 68978329HCID 68978329, compound

Product 1

HCID 11466575HCID 11466575, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Prepared from 2-{3-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl]phenyl}-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (Preparation 27) according to the method for example 3 to give the title compound as a white foam after trituration with ether.

Sources & evidence

ORD record
ord-96296f252050419eb7d79ebe7356e7c8
Source dataset
uspto-grants-2007_09
Patent number
US07268147B2

Reaction notes

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