Dichloromethane → Ammonia

Participants

Reaction Steps

Prepared from 4-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[((1R)-2-{3-[3-(3,4-dihydroisoquinolin-2-(1H)-yl)-3-oxopropyl]phenyl}-1-methylethyl)amino]ethyl}-2-(hydroxymethyl)phenol (Preparation 50) according to the method for example 1 using methanol:water (2.4:1 v/v) instead of acetic acid as solvent and using dichloromethane:methanol: 880 ammonia (95:5:0.5 by volume) as the column eluent to give the title compound as a white solid.

Provenance & Evidence