Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

Fmoc-L-Ile-AE (19 mg; 0.0314 mmol) was treated with piperidine (0.05 ml; 0.502 mmol) in dichloromethane (2 ml) for 1 hr. The solvent and piperidine were removed under vacuum. The residue was suspended in n-hexane and centrifuged. Once the supernatant solvent was removed, the solid obtained was treated with HCl in ethanol (2 ml). Solvent evaporation gave L-Ile-AE×HCl (10 mg; 77%).

Provenance & Evidence