反应详情

To 133 (10.014 g, 26.2 mmol) in 1,4-dioxane (80 mL) was added slowly methyl-(1-methyl-piperidin-4-yl)-amine (3.8 mL, 26.2 mmol) dissolved in 1,4-dioxane (15 mL) by addition funnel. Then aqueous sodium hydroxide (10.5 mL, 2.5 N, 26.2 mmol) was added by addition funnel followed by water (26 mL). The reaction mixture was heated at reflux for about 2.5 hours under a nitrogen atmosphere. The reaction was cooled and diluted with methylene chloride. The reaction mixture was filtered using vacuum and the white solid 147 removed. The filtrate was then washed 1 time with brine. The aqueous layer was back extracted 1 time with methylene chloride. The organic layers were combined and dried over potassium carbonate. The organic solution was filtered and concentrated in vacuo to afford the crude product (5.89 g). The crude reaction product was purified by flash column chromatography (silica gel) eluting with 96:3:1 methylene chloride:methanol:15 M ammonium hydroxide. The fractions were combined, dried over sodium sulfate/potassium carbonate, filtered, and concentrated in vacuo to afford 137 as a white solid (3.84 g, 30.9%), mp 104-105° C.; HPLC: YMC Pack Pro C18, 40:30:30 [KH2PO4 (0.01 M, pH 3.2): CH3OH:CH3CN], 264 nm, Rt 13.8 min, 97% purity); MS (ESI): m/z 474 (M+H, 41), 408 (2.3), 364 (2.8), 258 (13), 239 (14), 239 (47.5), 238 (100), 127 (5.3).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for about 2.5 hours under a nitrogen atmosphere
3. temperatureThe reaction was cooled
4. filtrationThe reaction mixture was filtered
5. customthe white solid 147 removed
6. washThe filtrate was then washed 1 time with brine
7. extractionThe aqueous layer was back extracted 1 time with methylene chloride
8. dry with materialdried over potassium carbonate
9. filtrationThe organic solution was filtered
10. concentrationconcentrated in vacuo
11. customto afford the crude product (5.89 g)
12. customThe crude reaction product
13. customwas purified by flash column chromatography (silica gel)
14. washeluting with 96:3:1 methylene chloride
15. dry with materialdried over sodium sulfate/potassium carbonate
16. filtrationfiltered
17. concentrationconcentrated in vacuo