反应详情

To a solution of potassium hydroxide (0.17 g, 2.95 mmol) in ethanol (20 ml) is added 2-[1-methyl-3-oxo-3-(4-fluorophenyl)-propenylamino]-3-(4-hydroxyphenyl)-propionic acid methyl ester (1.05 g, 2.95 mmol) and 1,2-dibromoethane (5.54 g, 29.50 mmol). Then the mixture is heated to reflux for 8 hours. After cooled, the reaction mixture is filtered to remove the solid formed, and then the filtrate is evaporated under a vacuum. The crude product is purified by silica gel chromatography using hexane/EtOAc (4:1) as eluent to give the title compound (0.37 g, 27%).

1. temperatureThen the mixture is heated
2. temperatureto reflux for 8 hours
3. temperatureAfter cooled
4. filtrationthe reaction mixture is filtered
5. customto remove the solid
6. customformed
7. customthe filtrate is evaporated under a vacuum
8. customThe crude product is purified by silica gel chromatography