Carbazole → HCID 67133134, compound

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Reaction Steps

To a solution of 2-((2-benzoylphenyl)amino)-3-[4-(2-bromoethoxy)-phenyl]-propionic acid methyl ester (240 g, 0.49 mol) and carbazole (82 g, 0.49 mol) in benzene (3000 ml) is added tetrabutyl ammonium bromide (80 g) and 40% NaOH aqueous solution (105 g, 1.05 mol), then the mixture is heated to reflux for 10 h. After cooled, the upper organic layer is evaporated under a vacuum. The crude product is purified by silica gel chromatography using CHCl3/MeOH (8:1) as eluent to give the title compound (78 g, 28.7%).

Provenance & Evidence