Carbazole → HCID 67133322, compound

Participants

Reaction Steps

To a solution of 2-[(2-(4-fluorobenzoyl)phenyl)amino]-3-[4-(2-bromoethoxy)-phenyl]-propionic acid methyl ester (250 g, 0.50 mol) and carbazole (83.5 g, 0.50 mmol) in benzene (3000 ml) is added tetrabutyl ammonium bromide (80 g) and 40% NaOH aqueous solution (108 g, 1.08 mol), then the mixture is heated to reflux for 10 h. After cooled, the upper organic layer is evaporated under a vacuum. The crude product is purified by silica gel chromatography using CHCl3/MeOH (8:1) as eluent to give the title compound (91.52 g, 32%).

Provenance & Evidence