HCID 5098631, compound → HCID 69419630, compound

Participants

Reaction Steps

Methyl 2-acetamido-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (0.8286 g, 2.68 mmol) was reductively desulfurized using Raney nickel to yield the title compound as a sticky white solid (0.7466 g, 2.63 mmol, 98.3%); mp: 73-75° C.; TLC: Rf=0.70 (Solvent I), 0.33 (Solvent J); IR (cm−1): 3261 (NH), 2943 (CH aliphatic), 1735 (ester C═O), 1648 (amide C═O), 1H nmr (CDCl3): δ 5.88 (br s, 1H), 3.69 (s, 3H), 3.53 (m, 1H), 3.41 (m, 1H), 3.34 (m, 1H), 2.44 (m, 1H), 1.94 (s, 3H), 1.77 (m, 2H), 1.63 (m, 1H), 1.50 (m, 1H), 1.27 (t, 1H, J=7.1 Hz), 1.00 (m, 4H), 0.82 (s, 9H).

Provenance & Evidence