Trifluoroacetic acid → 1-(4-Amino-benzyl)-3-phenyl-1H-indole indolecarboxylic acid ethyl ester

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Reaction Steps

1-(4-Amino-benzyl)-3-phenyl-1H-indole indolecarboxylic acid ethyl ester was prepared from 1-(4-nitro-benzyl)-3-phenyl-1H-indolecarboxylic acid ethyl ester followed the procedure of Example 1 Step 1 as a yellow syrup: 1H NMR (DMSO-d6) δ 0.98 (t, J=7.2 Hz, 3H), 4.11 (q, J=7.2 Hz, 2H), 4.99 (br s, 2H), 5.59 (s, 2H), 6.44 (d, J=8.41 Hz, 2H), 6.85 (d, J=8.4 Hz, 2H), 7.13 (td, J=7.1, 0.8 Hz, 1H), 7.34 (td, J=7.1, 0.8 Hz, 1H), 7.38-7.41 (m, 3H), 7.44-7.49 (m, 3H), 7.69 (d, J=8.4 Hz, 1H); MS (ESI) Hz 371 (MH+); 369 ([M−H]−); Anal. calcd for C24H22N2O2.0.04 TFA C, 71.12; H, 5.92; N, 7.47. Found: C, 71.03; H, 5.87; N, 7.36.

Provenance & Evidence