HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 1h-Indole-2-carboxylic acid,1-[[4-[(methylsulfonyl)amino]phenyl]methyl]-3-(2-thienyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1h-Indole-2-carboxylic acid,1-[(4-nitrophenyl)methyl]-3-(2-thienyl)-,ethyl ester | HCID 69435541 | — |
| Product | 1h-Indole-2-carboxylic acid,1-[[4-[(methylsulfonyl)amino]phenyl]methyl]-3-(2-thienyl)- | HCID 11418894 | — |
Reaction Steps
The title compound was prepared from 1-(4-nitro-benzyl)-3-thiophene-2-yl-1H-indole-2-carboxylic acid ethyl ester and methanesulfonyl chloride followed the procedure of Example 3 Step 2 as a light yellow solid: 1H NMR (DMSO-d6) δ 2.94 (s, 3H), 5.76 (s, 2H), 7.08-7.24 (m, 7H), 7.34 (td, J=8.4, 1.2 Hz, 1H), 7.60-7.70 (m, 3H), 9.69 (br s, 1H), 13.25 (br s, 1H); MS (ESI) m/z 427 (MH+); MS (ESI) m/z 425 ([M−H]−); HRMS calcd for C21H19N2O4S2: 427.0784; found (ESI+): 427.0779.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268159B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-af0d50102870463eaf6ec5fea061781d |
| Source note | uspto-grants-2007_09 |