N,N-Diethylpiperidine-3-carboxamide → 1-(4-Cyanonaphthalen-1-yl)piperidine-3-carboxylic acid diethylamide

Participants

Reaction Steps

A solution of 1-cyano-4-fluoronaphthalene in pyridine (0.6 M, 1 mL) was transferred to a Pyrex tube and N,N-diethylnipecotamide (447 mg, 2.4 mmol) was added. The tube was capped and the reaction tube was exposed to microwave irradiation (220° C., 10 min). The reaction mixture was concentrated and purified according to Purification Method A.

Provenance & Evidence