Pyrrolidine → HCID 91995409, compound

Participants

Reaction Steps

Pyrrolidine (5.0 mL) was added to 1-chloro-4,8-dinitronaphthalene (50 mg, 0.20 mmol, Bassilios et al, Recueil, 1962, 81, 209-214) which resulted in an immediate, highly exothermic reaction. The reaction was further agitated for 5 min while heating using a heatgun. Volatiles were removed in vacuo and purification as in 159JP06 (dichloromethane/n-heptane 4:1, 5× eluted) afforded 12 mg (21%) of 159JP29 as an orange solid. The product was converted to the corresponding hydrochloride salt as described above.

Provenance & Evidence