(4-Pyrrolidin-1-ylnaphthalen-1-yl)phosphonic acid diethyl ester → HCID 11536812, compound

Participants

Reaction Conditions

Reaction Steps

(4-Pyrrolidin-1-ylnaphthalen-1-yl)phosphonic acid diethyl ester 139MBT64-B (40 mg, 0.11 mmol) was dissolved in pyrrolidine (0.5 mL) and the mixture was heated to 80° C. for 20 hours. The mixture was concentrated and the crude product was purified by preparative TLC (0-10% methanol in dichloromethane) to give the title compound (20 mg, 55%) as a white solid.

Provenance & Evidence