(±)-Cytisine → HCID 11551865, compound

HRID 916333Notes

Reaction equation

HRID 916333 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[O:14]=[C:15]1[N:20]2[CH2:21][CH:22]3[CH2:27][CH:26]([C:19]2=[CH:18][CH:17]=[CH:16]1)[CH2:25][NH:24][CH2:23]3>>[O:14]=[C:15]1[N:20]2[CH2:21][CH:22]3[CH2:27][CH:26]([C:19]2=[CH:18][CH:17]=[CH:16]1)[CH2:25][N:24]([C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)[CH2:23]3

Participants

3

Reactant 2

HCID 22407(±)-CytisineHCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 11551865HCID 11551865, compoundYield 8%

Procedure

The title compound (3 mg, 8% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 8-oxo-1,5,6,8-tetrahydro-2H,4H-1,5-methanopyrido[1,2-a][1,5]diazocine (89 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-6f12e56ec33444d39d830c72af0a04f5
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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