1-Cyano-4-fluoronaphthalene → HCID 69223945, compound

HRID 916339Notes

Reaction equation

HRID 916339 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[OH:14][C@:15]12[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]1[CH2:19][NH:18][CH2:17][CH2:16]2>>[OH:14][C@:15]12[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]1[CH2:19][N:18]([C:6]1[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)[CH2:17][CH2:16]2

Participants

3

Reactant 2

HCID 27367341-Cyano-4-fluoronaphthaleneHCID 69226998HCID 69226998, compound

Product 1

HCID 69223945HCID 69223945, compoundYield 22.3%

Procedure

The title compound (8 mg, 22% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and (S)-4a-hydroxyoctahydroisoquinoline (73 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-2ce5c3e045344facb4b48f923037949c
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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