6-Methoxy-1,2,3,4-tetrahydroisoquinoline → HCID 11507918, compound

HRID 916340Notes

Reaction equation

HRID 916340 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH2:22][NH:21][CH2:20][CH2:19]2>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH2:22][N:21]([C:6]1[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)[CH2:20][CH2:19]2

Participants

3

Reactant 2

HCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinolineHCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 11507918HCID 11507918, compoundYield 19%

Procedure

The title compound (7 mg, 19% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 6-methoxy-3,4-dihydro-1H-isoquinoline (76 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-8c138dd885b640b08db19d8cbee8b306
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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