1-Cyano-4-fluoronaphthalene → HCID 69227670, compound

HRID 916341Notes

Reaction equation

HRID 916341 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[C:14]1([NH:20][CH2:21][C@H:22]2[CH2:26][CH2:25][CH2:24][NH:23]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([NH:20][CH2:21][C@H:22]2[CH2:26][CH2:25][CH2:24][N:23]2[C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 27367341-Cyano-4-fluoronaphthaleneHCID 6950383(R)-(-)-2-(Anilinomethyl)pyrrolidine

Product 1

HCID 69227670HCID 69227670, compoundYield 18.3%

Procedure

The title compound (7 mg, 18% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and (R)-(−)-2-phenylaminomethylpyrrolidine (82 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-a13a12a90f764503a8ef4c910266c288
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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