8-Azabicyclo(3.2.1)octane → 4-(8-Azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile

Participants

Reaction Steps

Alternatively, the title compound was also obtained using the following procedure: 8-Azabicyclo[3,2,1]octane (20 mg, 0.18 mmol), 1-cyano-4-fluoronaphthalene (46 mg, 0.27 mmol) and pyridine (0.5 mL) were heated overnight at 100° C., concentrated in vacuo and the residue purified by preparative TLC (dichloromethane, 3× eluted) to afford the title compound (1.8 mg, 4.0%) as a yellow oil.

Provenance & Evidence