1-Cyano-4-fluoronaphthalene → HCID 69225857, compound

Participants

Reaction Steps

8-Azabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester (225 mg, 1.35 mmol, Davies H. M. L. et al., J. Org. Chem. 1991, 56, 5696-5700), 1-cyano-4-fluoronaphthalene (230 mg, 1.35 mmol) and pyridine (1.0 mL) were heated to 110° C. for 2 days and concentrated in vacuo. The residue was purified by preparative TLC (ethyl acetate/n-heptane 1:4, 5× eluted) to afford the title compound (25 mg, 6%) as a colorless oil.

Provenance & Evidence