HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloropropionyl chloride → 3-Chloro-N-[8-(4-cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(3-Amino-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile, hydrochloride | HCID 131726600 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Chloro-N-[8-(4-cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]propanamide | HCID 69226595 | — |
Reaction Steps
This compound was synthesized in the same way as 165RL23 using 165RL21 (320 mg, 1.15 mmol), 3-chloropropionyl chloride (120 μL, 1.27 mmol), DIPEA (220 μL, 1.27 mmol) and DMF (10 mL). The crude product was purified by column chromatography using ethyl acetate/MeOH (95:5) to give the title compound (318 mg, 75
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268232B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-208bb48df15845b295e5dad49d6238ac |
| Source note | uspto-grants-2007_09 |