Potassium Carbonate → n-[8-(4-Cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-3-(4-ethylpiperazin-1-yl)propanamide, dihydrochloride

Participants

Reaction Steps

165RL50 (65 mg, 0.18 mmol), 1-ethylpiperazine (45 μL, 0.35 mmol) and potassium carbonate (49 mg, 0.35 mmol) were stirred in acetonitrile (6 mL) at 50° C. for 2 days. The reaction mixture was diluted with ethyl acetate (15 mL) and washed with water (2×10 mL). The organic solution was dried over sodium sulfate, filtered and evaporated. The product was purified by column chromatography using ethyl acetate/MeOH (9:1) to give the title compound (37 mg, 46%) pure product.

Provenance & Evidence