HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → n-[8-(4-Cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-3-diethylaminopropionamide, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-N-[8-(4-cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]propanamide | HCID 69226595 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | n-[8-(4-Cyanonaphthalen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-3-diethylaminopropionamide, hydrochloride | HCID 131726602 | 19% |
Reaction Steps
The title compound (16 mg, 19%) was synthesized in the same way as 165RL52 using 165RL50 (80 mg, 0.21 mmol), diethylamine (45 μL, 0.44 mmol), potassium carbonate (60 mg, 0.44 mmol) and acetonitrile (6 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268232B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-5889cd25370d477883d3601c4fd0972b |
| Source note | uspto-grants-2007_09 |