HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromo-5,5-dimethylhydantoin → 5-Bromo-2,3-dihydro-7-azaindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromo-5,5-dimethylhydantoin | HCID 6479 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 1H,2H,3H-pyrrolo(2,3-b)pyridine | HCID 10011889 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-2,3-dihydro-7-azaindole | HCID 21964079 | — |
Reaction Steps
The bromination may be carried out by any of the procedures known for such a reaction. The bromination may be carried out, for example, by mixing 7-azaindoline, p-toluene sulphonic acid monohydrate and 1,3-dibromo-5,5-dimethylhydantoin in methylene chloride and stirring the mixture at for example ambient temperature for a period of time, for example 3 hours. Extraction and purification gives 5-bromo-7-azaindoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268230B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-57567878b97c4b3cb517a6a44bee1c54 |
| Source note | uspto-grants-2007_09 |