反应详情

A mixture of 5-bromo-7-azaindoline (15.6 g, 78 mmol) and precipitated, active manganese (IV) oxide (21.9 g, 252 mmol) in toluene (300 mls) was heated at 90° C. for 1 hour and the hot solution filtered through a pad of diatomaceous earth. The diatomaceous earth and manganese residues were washed with acetone and these washings added to the toluene filtrate. Evaporation of the filtrate under vacuum gave 5-bromo-7-azaindole (12.1 g, 78%).

1. customprecipitated
2. filtrationthe hot solution filtered through a pad of diatomaceous earth
3. washThe diatomaceous earth and manganese residues were washed with acetone
4. additionthese washings added to the toluene filtrate
5. customEvaporation of the filtrate under vacuum