7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline

HRID 916399Notes

Reaction equation

HRID 916399 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(Cl)Cl>[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 220308367-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride

Product 1

HCID 106619987-(Benzyloxy)-4-chloro-6-methoxyquinazolineYield 97.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-Benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.35 g) was dissolved in methylene chloride (250 ml) and washed with aqueous sodium hydrogen carbonate until the pH of the aqueous solution was adjusted to pH8. The organic layer was washed with brine, dried (MgSO4) and evaporated to give 7-benzyloxy-4-chloro-6-methoxyquinazoline free base (2.9 g, 96%).

Workup

  1. washwashed with aqueous sodium hydrogen carbonate until the pH of the aqueous solution
  2. washThe organic layer was washed with brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-6165871680284d6d8b422fa2e6ea2b69
Source dataset
uspto-grants-2007_09
Patent number
US07268230B2

Reaction notes

Loading…