Thionyl Chloride → HCID 87822203, compound

Participants

Reaction Steps

A solution of 3-{[2-(9H-fluoren-9-yl)-ethyl]-methyl-amino}-propionic acid (11.4 g) in dichloroethane (115 ml) is treated with thionyl chloride (7.71 g) at room temperature for 5′ and at 60° for 1 hour. About 20 ml volatiles are removed under reduced pressure. 100 ml diethyl ether are added and the mixture kept at 5° over night for crystallization. The crystals are collected by filtration, washed with dichloroethane/diethylether and dried. M.p. 120°-123°.

Provenance & Evidence