Sodium Hydroxide → HCID 22934932, compound

HRID 916573Notes

Reaction equation

HRID 916573 reaction equation
C([NH:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>CO>[NH2:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([CH2:19][CH3:20])=[CH:17][CH:18]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22934954HCID 22934954, compound

Product 1

HCID 22934932HCID 22934932, compoundYield 8.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 6-(N-acetylamino)-3-(4-ethylbenzyl)-1H-pyridin-2-one (0.19 g) in methanol (1 mL) was added 2 mol/L aqueous sodium hydroxide solution (0.35 mL), and the mixture was added for 22 hours at 80° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: dichloro-methane/methanol=6/1) to give 6-amino-3-(4-ethylbenzyl)-1H-pyridin-2-one (0.013 g).

Workup

  1. additionthe mixture was added for 22 hours at 80° C
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe residue was purified by column chromatography on silica gel (eluent: dichloro-methane/methanol=6/1)

Sources & evidence

ORD record
ord-a59f4aea9de6457d9248d6de7abb9a0a
Source dataset
uspto-grants-2007_09
Patent number
US07271153B2

Reaction notes

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