反应详情

To a solution of 6-(N-acetylamino)-3-(4-ethylbenzyl)-1H-pyridin-2-one (0.19 g) in methanol (1 mL) was added 2 mol/L aqueous sodium hydroxide solution (0.35 mL), and the mixture was added for 22 hours at 80° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: dichloro-methane/methanol=6/1) to give 6-amino-3-(4-ethylbenzyl)-1H-pyridin-2-one (0.013 g).

1. additionthe mixture was added for 22 hours at 80° C
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was purified by column chromatography on silica gel (eluent: dichloro-methane/methanol=6/1)