Bromotrimethylsilane → HCID 69015383, compound

Participants

Reaction Steps

To a solution of 2-(β-D-glucopyranosyloxy)-3-[4-(2-methoxymethyloxyethyl)benzyl]-4,6-dimethylpyridine (0.054 g) in dichloromethane (1.2 mL) was trimethylbromosilane (0.061 mL) at −23° C., and the mixture was stirred for 10 minutes. To the reaction mixture was added saturated aqueous sodium bicarbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by preparative thin layer chromatography on silica gel (developing solvent: dichloromethane/methanol=6/1) to give 2-(β-D-glucopyranosyloxy)-3-[4-(2-hydroxyethyl)benzyl]-4,6-dimethylpyridine (0.008 g).

Provenance & Evidence