Sodium Hydroxide → HCID 10130593, compound

HRID 916608Notes

Reaction equation

HRID 916608 reaction equation
C([N:4]1[CH2:16][C:14]2=[C:15]3[C:10](=[CH:11][CH:12]=[CH:13]2)[C@H:9]2[CH2:17][CH2:18][CH2:19][C@H:8]2[N:7]3[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>CO>[CH2:6]1[N:7]2[C:15]3[C:10]([CH:9]4[CH2:17][CH2:18][CH2:19][CH:8]42)=[CH:11][CH:12]=[CH:13][C:14]=3[CH2:16][NH:4][CH2:5]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69263493HCID 69263493, compound

Product 1

HCID 10130593HCID 10130593, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(7bR, 10aR)-3-Acetyl-1,2,3,4,8,9, 10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1-hi]indole was treated with solid NaOH in MeOH under reflux to give 7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1-hi]indole mp: 57-59° C.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-e822223a8bf942ed9a2da128ffffe018
Source dataset
uspto-grants-2007_09
Patent number
US07271163B2

Reaction notes

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