反应详情

NaOMe (1.30 g, 24 mmol) is added to a stirred solution of formamidine (12 mmol) in MeOH (75 ml) at room temperature. The mixture is stirred for 15 minutes. 2-Acetyl-pentanoic acid methyl ester (10 mmol) is added and the mixture is stirred at room temperature overnight. Acetic acid (0.72 g, 12 mmol) is added and the solvent is removed in vacuo. Water (30 ml) is added to the residue and it is extracted with 2-butanone (3×30 ml). The combined extracts are washed with brine (40 ml), dried (Na2SO4) and evaporated, to provide a yellow solid (100), which is used in the next step without further purification.

1. stirringthe mixture is stirred at room temperature overnight
2. customthe solvent is removed in vacuo
3. additionWater (30 ml) is added to the residue and it
4. extractionis extracted with 2-butanone (3×30 ml)
5. washThe combined extracts are washed with brine (40 ml)
6. dry with materialdried (Na2SO4)
7. customevaporated