HCID 57503301, compound → HCID 57503302, compound

HRID 916645Notes

Reaction equation

HRID 916645 reaction equation
[N:1]([C:4]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:8]([CH2:13][N:14]2[CH:18]=[CH:17][N:16]=[C:15]2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[N:20]=2)[N:7]=[C:6]([CH3:26])[N:5]=1)=[N+]=[N-]>CO.[Pd]>[NH2:1][C:4]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:8]([CH2:13][N:14]2[CH:18]=[CH:17][N:16]=[C:15]2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[N:20]=2)[N:7]=[C:6]([CH3:26])[N:5]=1

Participants

4

Reactant 1

HCID 57503301HCID 57503301, compound

Product 1

HCID 57503302HCID 57503302, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (10%, 10 mg) is added to a solution of 4-azido-6-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-2-methyl-5-propyl-pyrimidine (2 mmol) (125) in MeOH (20 ml) and the mixture is stirred under H2 at 30 psi for 4 hours. The catalyst is filtered out and the filtrate is evaporated in vacuo. The resulting light yellow solid (126) is used in the next step without further purification.

Workup

  1. filtrationThe catalyst is filtered out
  2. customthe filtrate is evaporated in vacuo
  3. customThe resulting light yellow solid (126) is used in the next step without further purification

Sources & evidence

ORD record
ord-abb87ae65e144dad96b9aece768c9512
Source dataset
uspto-grants-2007_09
Patent number
US07271170B2

Reaction notes

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