Phosphorus oxychloride → HCID 11325890, compound

Participants

Reaction Steps

POCl3 (0.5 ml) is added to a solution of 128 (0.75 mmol) in pyridine (3 ml) and the mixture is stirred at room temperature overnight. The solvent is evaporated and the residue is purified by PTLC (5% MeOH in CH2Cl2) to afford the product (127); LC-MS, M+1 362.1; 1H-NMR (CDCl3) δ: 8.77 (s, 1H), 8.11 (dd, 1H), 8.03 (s, 1H), 7.82 (q, 1H), 7.19 (s, 1H), 7.18 (s, 1H), 6.82 (dd, 1H), 6.03 (s, 2H), 3.11–3.17 (m, 2H), 1.67–1.75 (m, 2H), 1.01 (t, 3H).

Provenance & Evidence