Carbon Dioxide → HCID 11210875, compound

Participants

Reaction Steps

To a solution {7-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}-methanol (compound 223, below) (31 mg, 0.08 mmol) in dichloromethane (5 mL) is added bis(2-methoxyethyl)aminosulfur trifluoride (0.2 ml, 50% in THF) at room temperature under N2. The mixture is stirred for two hours, and is poured into saturated NaHCO3 (10 mL), and after CO2 evolution ceases it is extracted into dichloromethane, dried (MgSO4), filtered and evaporated in vacuo. PTLC by 5% MeOH/dichloromethane gives the pure product (157). 1H NMR: 0.98 (3H, t, J=5.4 Hz), 1.67 (2H, m), 2.99 (2H, m), 5.69 (2H, d, J=35.1 Hz), 5.88 (2H, s), 7.22 (1H, s), 7.22–7.31 (2H, m), 7.54 (1H, t, J=6.0 Hz), 8.39 (1H, s), 9.13 (1H, s). LCMS (M+1) 370.20.

Provenance & Evidence