Pyrrolidine → HCID 11281211, compound

Participants

Reaction Steps

A mixture of 175 (77 mg, 0.185 mmol) and pyrrolidine (0.5 ml) is stirred at room temperature for 4 hours. The solvent is removed in vacuo and the residue is partitioned between water (5 ml) and EtOAc (5 ml). The layers are separated and the aqueous layer is extracted with EtOAc (2×5 ml). The combined extracts are washed with brine (5 ml), dried (Na2SO4) and evaporated. PTLC separation of the residue with 5% MeOH in CH2Cl2 gives the title compound 173 as a white solid. H1 NMR (δ, CDCl3): 8.84 (s, 1H), 8.40 (m, 1H), 7.51–7.56 (m, 1H), 7.21–7.31 (m, 2H), 7.18 (s, 1H), 5.76 (s, 2H), 3.53–3.57 (m, 4H), 2.80–2.84 (m, 2H), 1.99–2.02 (m, 4H), 1.58–1.64 (m, 2H), 0.93 (t, 3H). LC-MS (M+1), 407.10.

Provenance & Evidence