Methylhydrazine → HCID 69424588, compound

Participants

Reaction Steps

EtOH (20 mL) and methyl hydrazine (162 μL, 3.05 mmol) were added to the product of Step 1 (630 mg, 2.04 mmol) and the mixture heated at reflux for 90 min. The solvent was removed under reduced pressure and the residue purified by column chromatography on silica eluting with 40% EtOAc/iso-hexanes to yield first 3-{5-[2-(4-fluorophenyl)-ethyl]-1,4-dimethyl-1H-pyrazol-3-yl}-benzonitrile (213 mg, 33%) (byproduct) and then the desired 3-{3-[2-(4-fluorophenyl)-ethyl]-1,4-dimethyl-1H-pyrazol-5-yl}-benzonitrile (250 mg, 38%).

Provenance & Evidence