反应详情

2-Bromo-4-nitro-benzonitrile (0.5 gm, 2.34 mmol) was hydrolysed using H2SO4 (2.2 ml) in 2.7 ml water at 80° C. for 8 hrs. After completion of reaction solution was poured over crushed ice, basified with sodium carbonate and extracted with ethyl acetate. Aqueous layer was separated, acidified with 1:1 HCl and extracted with ethyl acetate. Combined organic layer was then concentrated to obtained compound(51).

1. customat 80° C.
2. customfor 8 hrs
3. customAfter completion of reaction solution
4. additionwas poured
5. customover crushed ice
6. extractionextracted with ethyl acetate
7. customAqueous layer was separated
8. extractionextracted with ethyl acetate
9. concentrationCombined organic layer was then concentrated
10. customto obtained compound(51)