反应详情

To a pressure tube with dioxane (5 mL) was added 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, then ammonia hydroxide (5 mL). The pressure tube was sealed and heated at 120 C overnight. All solvents were removed via reduced pressure, and the residue were purified through flash column (methylene chloride/methanol:97/3). The product was obtained as a white solid (300 mg, 92%). MS: 329.1 (MH+); HPLC Rf: 5.018 min.; HPLC

1. customThe pressure tube was sealed
2. temperatureheated at 120 C overnight
3. customAll solvents were removed via reduced pressure
4. customthe residue were purified through flash column (methylene chloride/methanol:97/3)