(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanone → (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-2-methyl-phenyl)methanone

HRID 916782Notes

Reaction equation

HRID 916782 reaction equation
Cl[C:2]1[C:3]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[C:14]=3[CH3:22])=[O:12])=[CH:9][N:8]([CH:23]([CH3:25])[CH3:24])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:26]C1C2C(C(C3C=CC=C(N)C=3)=O)=CN(C3CCCC3)C=2N=CN=1>>[NH2:26][C:2]1[C:3]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[C:14]=3[CH3:22])=[O:12])=[CH:9][N:8]([CH:23]([CH3:25])[CH3:24])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 11859044(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanoneHCID 86760551(4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-methyl-3-nitro-phenyl)-methanone

Product 1

HCID 67219452(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-2-methyl-phenyl)methanone

Procedure

The title compound was prepared from (4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-methyl-3-nitro-phenyl)-methanone by procedures analogous to those described for the preparation of (4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanone. MS: 310.1 (MH+); HPLC Rf: 1.3 min. (HPLC method 2); HPLC purity: 100%.

Sources & evidence

ORD record
ord-e4746585324f4ba18c0b8c5a0f0b8d3a
Source dataset
uspto-grants-2007_09
Patent number
US07271262B2

Reaction notes

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