5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine → (3-Amino-2-chloro-phenyl)-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine	HCID 45789428	—
Reactant	(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-2-methyl-phenyl)methanone	HCID 67219452	—
Reactant	2-Chloro-N-methoxy-N-methyl-3-nitro-benzamide	HCID 86596500	—
Product	(3-Amino-2-chloro-phenyl)-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone	HCID 67219553	—

Reaction Steps

The title compound was prepared from 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine and 2-Chloro-N-methoxy-N-methyl-3-nitro-benzamide by procedures analogous to those described for the preparation of (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-2-methyl-phenyl)-methanone. MS: 330.3 (MH+); HPLC Rf: 1.6 min. (HPLC HPLC purity: 99%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07271262B2
Source dataset	uspto-grants-2007_09
ORD ID	ord-a2582f8f634048489e458daf2087ddb2
Source note	uspto-grants-2007_09