Methanesulfonyl chloride → 1-{3-[4-Amino-7-(1-methanesulfonyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-phenyl}-3-(3,5-dichloro-phenyl)-urea

참여 물질

역할	이름	HCID	투입량
반응물	Methanesulfonyl chloride	HCID 31297	—
반응물	1-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea	HCID 67219862	—
용매	dichloromethane N,N-dimethylformamide	HCID 22350042	—
생성물	1-{3-[4-Amino-7-(1-methanesulfonyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-phenyl}-3-(3,5-dichloro-phenyl)-urea	HCID 67218832	19%

반응 단계

A solution of 1-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea (100 mg, 0.19 mmol) and methanesulfonylchloride (22 mg, 0.19 mmol) in DMF/CH2Cl2 (2/3, 5 mL) was stirred in a sealed tube for 1.5 hours at room temperature. The reaction mixture concentrated in vacuo. Purification by reverse phase preparative HPLC (HPLC method 2) provided the title compound as a white solid (21.8 mg, 19%). MS: 603.5 (MH+); HPLC Rf: 2.3 min. (HPLC method 2); HPLC purity: 100%.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07271262B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-fc6577b2e84144dca34199561fe47c15
출처 메모	uspto-grants-2007_09