HCID 69386463, compound → HCID 69385147, compound

Participants

Reaction Conditions

Reaction Steps

3-{[2-(4-{2-[(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]ethyl}phenoxy)ethoxy]methyl}benzonitrile (125 mg) in THF (3 mL) was treated with KOSiMe3 (152 mg) and the resulting solution was heated at 75° C. for 4 h. The reaction mixture was then quenched with MeOH and concentrated in vacuo. The residue was taken up in EtOAc, washed with phosphate buffer (pH=6.5) and water, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography (SPE, 5 g) eluting with CH2Cl2-MeOH-2M NH3 in MeOH (196:3:1) and then CH2Cl2: MeOH: 2M NH3/MeOH (96:3:1) to give the title compound (42 mg). LCMS RT=2.40 min.

Provenance & Evidence