HCID 69406722, compound → HCID 10174650, compound

Participants

Reaction Steps

3-({2-[4-(2-{[(2R)-2-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}ethyl)phenoxy]ethoxy}methyl)-N,N-bis{[2-(trimethylsilyl)ethoxy]methyl}benzenesulfonamide (0.015 g) was heated at 75° for 6 h in acetic acid (1.5 ml) and water (0.75 ml). The solution was evaporated to dryness and re-evaporated twice with methanol to give crude product (0.012 g). This was purified by preparative layer chromatography on a silica plate (20×20 cm) which was developed twice in dichloromethane:ethanol: 0.880 ammonia solution, 25:8:1. After elution of the required band using methanol in dichloromethane, the eluate was evaporated to dryness and re-evaporated successively with acetic acid in methanol and then methanol to give the title compound (0.0037 g) LCMS RT=2.19 min. ES+ve 517 (MH)+

Provenance & Evidence