HCID 69391369, compound → HCID 69387222, compound

Participants

Reaction Steps

N-(tert-Butoxycarbonyl)-N-[3-({2-[4-(2-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}ethyl)phenoxy]ethoxy}methyl)phenyl]sulfamide (15 mg) in acetic acid (1.5 ml) and water (0.5 ml) was heated at 75° C. for 0.5 h. The solution was then concentrated in vacuo and azeotroped with MeOH. The residue was purified by HPLC to give the title compounds N-{3-[(2-{4-[2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]phenoxy}ethoxy)methyl]phenyl}sulfamide formate (1.5 mg) LCMS RT=2.21 min, ES+ve 532 (MH)+and N-(tert-butoxycarbonyl)-N-{3-[(2-{4-[2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]phenoxy}ethoxy)methyl]phenyl}sulfamide formate (0.9 mg). LCMS RT=2.51 min ES+ve 630 (MH)+

Provenance & Evidence